We completed an ambitious research program which was divided into nine research themes and covered three key disciplines: immunology, chemistry and physics.
MOLECULAR IMAGING USING XFEL
Working on techniques to capture real-time molecular movies using ultrafast X-ray diffraction. Molecular movies using XFELs could allow scientists to track the intricacies, nuances and detailed behaviour of molecules like never before.
SINGLE MOLECULE IMAGING
Addressing the challenges associated with instrument fluctuations, electronic damage, natural conformational variability and the effects of confinement by developing new systems and tools to map the heterogeneity landscape of single molecules.
MOLECULAR IMAGING OF T CELL ACTIVATION
Understanding how antigens elicit an immune response and using single molecule imaging and other fluorescence techniques to map intracellular signalling processes.
IN VIVO IMAGING
Solving major questions about immune cell interactions, how responses are initiated and how various cells coordinate their functions. Using sophisticated imaging techniques to visualise multiple cellular interactions in real-time.
IMAGING METABOLITE-MEDIATED IMMUNITY
Using novel imaging reagents and imaging modalities developed within this theme, we are beginning to understand MAIT cell antigen recognition, activation, development and maintenance, and how these cells traffic in the host in response to infection.
IMAGING IMMUNE EFFECTORS
Working to gain a better understanding of the control of immune effectors. In the longer term, we anticipate using this information to control immune driven diseases.