We completed an ambitious research program which was divided into nine research themes and covered three key disciplines: immunology, chemistry and physics.
IMAGING
MOLECULAR IMAGING USING XFEL
Working on techniques to capture real-time molecular movies using ultrafast X-ray diffraction. Molecular movies using XFELs could allow scientists to track the intricacies, nuances and detailed behaviour of molecules like never before.
SINGLE MOLECULE IMAGING
Addressing the challenges associated with instrument fluctuations, electronic damage, natural conformational variability and the effects of confinement by developing new systems and tools to map the heterogeneity landscape of single molecules.
MOLECULAR IMAGING OF T CELL ACTIVATION
Understanding how antigens elicit an immune response and using single molecule imaging and other fluorescence techniques to map intracellular signalling processes.
IN VIVO IMAGING
Solving major questions about immune cell interactions, how responses are initiated and how various cells coordinate their functions. Using sophisticated imaging techniques to visualise multiple cellular interactions in real-time.
IMMUNOLOGY
IMAGING PEPTIDE-MEDIATED IMMUNITY
By developing atomic and molecular imaging innovations, this research will help to further understand T cell function and dysfunction.
IMAGING LIPID-MEDIATED IMMUNITY
Investigating the types of lipids that are responsible for lipid-mediated immunity in the context of both foreign and self-antigens.
IMAGING METABOLITE-MEDIATED IMMUNITY
Using novel imaging reagents and imaging modalities developed within this theme, we are beginning to understand MAIT cell antigen recognition, activation, development and maintenance, and how these cells traffic in the host in response to infection.
IMAGING INNATE IMMUNE RESPONSES
Uncovering what happens over time when innate immune cells are confronted with either infectious or non-infectious stimuli.
IMAGING IMMUNE EFFECTORS
Working to gain a better understanding of the control of immune effectors. In the longer term, we anticipate using this information to control immune driven diseases.