NOVEL IMMUNE-ONCOLOGY APPROACH FOR POTENTIAL CANCER TREATMENT
15 September 2020
A research collaboration between Monash University and Lava Therapeutics details a novel immune-oncology approach for the potential treatment of cancer. Instrumental to the study was co-first author Dr Roeland Lameris from Amsterdam UMC and colleagues from the University of Melbourne.
Published in Nature Cancer, the study, co-led by ARC Centre of Excellence in Advanced Molecular Imaging CI Professor Jamie Rossjohn and Monash Biomedicine Discovery Institute’s Dr Adam Shahine, highlights the synergy between an antibody fragment, known as a nanobody, that not only acts as a bridge helping to link together two key immune cell receptors but also takes advantage of their interaction, enabling the body to enhance its immune response to cancer.
These antibody fragments, denoted as nanobodies, act by targeting the interaction between a molecule known as CD1d and Natural Killer T cells (NKT) in a stable and long-lasting manner, against tumour samples of patients with multiple myeloma and acute myeloid leukemia
The new findings will serve as a model for the potential generation of new and effective therapies against a broad range of cancers.
Using the Australian Synchrotron, the team at Monash University provided detailed atomic insight into how the nanobodies exerted their effect on immune cells in a cancer model. “We were able to precisely visualize how the nanobody simultaneously recognized CD1d and the NKT TCR, thereby providing a molecular basis for their anti-tumour properties” Professor Rossjohn stated.
Hans van der Vliet, professor in medical oncology at Amsterdam UMC and chief scientific officer of Lava Therapeutics says “By targeting and boosting natural immune cells that are inherent in all humans, such as NKT cells and gamma-delta T cells, for an enhanced therapeutic effect, we believe our approach could ultimately translate into a broadly applicable immunotherapeutic approach for a range of cancer indications.”
“This collaborative work paves the way for rationally developing improved therapeutics to treat a range of cancers,” said co-first author Dr Shahine.
Read the full paper in Nature Cancer titled: “A single domain bispecific antibody targeting CD1d and the NKT T cell receptor induces a potent anti-tumour response”
This article was originally published by the Monash Biomedicine Discovery Institute
About the Monash Biomedicine Discovery Institute
Committed to making the discoveries that will relieve the future burden of disease, the newly established Monash Biomedicine Discovery Institute at Monash University brings together more than 120 internationally-renowned research teams. Our researchers are supported by world-class technology and infrastructure, and partner with industry, clinicians and researchers internationally to enhance lives through discovery.
About the ARC Centre of Excellence in Advanced Molecular Imaging
The $39 million ARC-funded Imaging CoE develops and uses innovative imaging technologies to visualise the molecular interactions that underpin the immune system. Featuring an internationally renowned team of lead scientists across five major Australian Universities and academic and commercial partners globally, the Centre uses a truly multi-scale and programmatic approach to imaging to deliver maximum impact. The Imaging CoE is headquartered at Monash University with four collaborating organisations – La Trobe University, the University of Melbourne, University of New South Wales and the University of Queensland.