Welcome to the 20’s!
Parsing the IL-37-Mediated Suppression of Inflammasome Function
26th Australian Conference on Microscopy and Microanalysis (ACMM)
Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease
Bacterial link in coeliac disease
Workshop on Cryo-EM Methods as part of the Lorne Conference
Discovery shines light on the cause of some allergic responses
Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1
ADVANCED IMAGING TIPS T CELL TARGET RECOGNITION ON ITS HEAD
Sensory Science Exhibition: Opening the world of cancer research to the low vision community
Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication
Sensitive disease diagnosis made more accessible with 3D printing
Single-molecule detection on a portable 3D-printed microscope
NEW GRANT TO CREATE BIOMEDICINE ROBOTIC ART
Viertel Fellowship supports research into immune escape
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
Biophysics Summer Project Scholarships
IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection
A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins
Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells
Mechanical Tuning of the Senses
PAPER: The Cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
2018 Annual Report
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
Monash University has become host to the new Victorian node of Microscopy Australia
PAPER: Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes
How a beer at a uni bar sparked an idea that could help save millions
6 December 2019 - Sensory Scientific Exhibition and Discovery Day
5-6 December 2019 - Wild and Comparative Immunology Workshop
28 November 2019 - Interactive Science Expo
15 November 2019 - BioPhotonics - Careers Workshop
11-13 November 2019 - ARC Centre of Excellence in Advanced Molecular Imaging – 2019 SUMMIT
31 October 2019 - MDHS ECR Network symposium
Saturday October 26 2019 – Sensory Science – An Exhibition to Stimulate the Senses (Perth)
18-20 September - New and Emerging Technologies 2019
10 August 2019 0 – Extra Sensory
ASI ADVANCED IMMUNOLOGY SCHOOL
Sensory Science in the running for Eureka Prize!
Centre AI A/Prof Laura Mackay named Eureka prize finalist
PAPER: PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro
PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
22 July 2019 ASI – Advanced Immunology School
Ultimate limitations in the performance of kinoform lenses for hard x-ray focusing
Paper: Ultimate limitations in the performance of kinoform lenses for hard X-ray focusing
5 July 2019 – Physics Symposium
Diverse MR1-restricted T cells in mice and humans
5 June 2019 – CRYOZ 2019: 2nd AMMS CRYO-EM SYMPOSIUM
IMAGING COE STUDENTS GAIN INTERNATIONAL RESEARCH EXPERIENCE
Seminar with Associate Professor Alexandra Ros
Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes
MP Steve Dimopoulos visits CoE
Top prize for imaging technology that detects disease
4.6 Million Dollar Wellcome Trust Funding for HIV Research
19 May 2019 – ARC Imaging CoE, XFEL Serial Crystallography 2019 Workshop
Seminar with Associate Professor Leonie Quinn
15 May 2019 – ARC IMAGING CoE presents: MICROFLUIDIC TOOLS FOR SERIAL CRYSTALLOGRAPHY: TIME RESOLVED STUDIES AND THE SAMPLE WASTE PROBLEM
Scientists reveal key mechanisms of vital enzyme complex
Ordered and Disordered Segments of Amyloid-β Drive Sequential Steps of the Toxic Pathway
Capturing How Amyloid Beta Initiates Death of Neuronal Cells With High-Speed Imaging
International placement for CoE students
Revealed: how the ‘Iron Man’ of immune cells helps T cells fight infection
3 May 2019 – The Australian & New Zealand Day of Immunology
Peptide papers point to new ways of tackling bacteria
22 March 2019 – Hunter Meeting Australia Systems | Cells | Development
Science without sight: bringing medical discovery to low vision community
News from the 2018 Imaging CoE Summit
14 January 2019 – 2019 SCANZ Australasian Crystallography School and ARC Centre of Excellence in Advanced Molecular Imaging Crystallography Workshop
International award for CI Kat Gaus
Mentoring takes two
Key to immune system’s memory revealed
In the news: Imaging CoE AI Assoc. Prof Kate Schroder
CI Rossjohn receives psoriasis research renewal
International opportunities: Student research placement and innovation tour to Germany
23 April 2018 – Serial Crystallography and Small Crystals Seminar at La Trobe University
12 Million in NHMRC Project Funding announced for our Investigators
Summer Scholarships
New Imaging CoE Operations Team
Twitter Chatter
Sweet Award for AI Gras
InnoHealth Australia: Call for applications
Double Fellowships for our CI’s
Paper: A molecule with more to say in autoimmune diseases
2017 Annual Report
Feeling Itchy? Inflammation could be scratched out
Eyes on: European XFEL
Finding the Future of Chemistry Leadership
Winston Churchill Travelling Fellow, Kristin Ladell, visiting Imaging CoE this month
International research partnership to accelerate impact of Australian discoveries
Completion of ARC mid-term review
Antibiotic insight may help in battle against bacterial resistance
New program for students boosts learning and data exchange
Every Minute Counts for New Collaboration
Playing the numbers: a billion-dollar gamble on the European X-ray Laser
Public lecture at Melbourne Knowledge Week
Single Particle Imaging, a doily and the FameLab Australia semi-finals!
Farewell and best wishes to Stephanie
Unearthing the basis of autoimmune disease
Charge sensors to watch the regulation of our T cells
Perspective on “Der Spiegel: Germany’s most expensive experiment”
Virus vs Host — an evolutionary arms race
Industry Engagement training @ Monash
New findings into gene regulation
Chris Lupton talks: industry engagement
Jeff Mak talks: chemical tools for research
New tool reveals how special immune cells fight bacteria
Formal collaboration with Cardiff University
19 NHMRC grants, totalling over $12 million, awarded to Imaging CoE researchers
Barcode scanner microscope films neurons firing
Understanding how HIV evades the immune system
UNEARTHING IMMUNE RESPONSES TO COMMON DRUGS
Postdoctoral Research Fellow – Protein Crystallography
‘Team Tiny Trap’ take top honours at Harvard
Super-bug fighting antibiotics
Crowning Imaging CoE CIs
News from the 2016 Imaging CoE Summit
Victoria’s status as biomedical research hub strengthened with major prize win
MASSIVE onboarding
Product release is rate-limiting for catalytic processing by Dengue virus protease
Rossjohn Lab job opportunity
Creating next generation medicines: new industry collaboration announced
2016 Imaging CoE Summit
ARC funds capability in cryo-electron microscopy and protein structural biology
Three new projects at the Elmlund lab
How our immune system targets TB
Communicating science with peers from different disciplines
Another brick in the celiac wall
Workshop on cryo-EM and single-particle analysis
Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit
German Academic Exchange Service scholarships now open!
Immune cell development secrets revealed
2016 Annual Report
Max Cryle talks: molecular machines
Journey to the centre of the cell: nano-rods and worms wriggle best
World’s most powerful X-ray takes a ‘sledgehammer’ to molecules
T Cell Signalling postdoc wanted for Single Molecule Microscopy Sydney, Australia
Illuminating structures with electrons
Blood Studies
‘Animal Farm’ immunity receptors only work in a crowd, researchers find
IMMUNE BREAKTHROUGH: UNSCRATCHING POISON IVY’S RASH
A physicist abroad
Bad diet damages the immune system even before weight gain
Capitalising on single turn helical structures
New technology to advance X-ray crystallography
Electrons and X-rays working together, spurring new ideas?
Malnutrition, shaping up to be a first world problem
Contactless Trampoline
Exploring the physics of imaging
Branch Moody visit
Einstein a Go Go in July
Mapping the diffusive route of transcription factors in live cell nuclear architecture
Physics Symposium – 16.1
Cryo-EM Data Analysis just got SIMPLE 2.1
EMBL Australia inaugural PhD program
Plasmonic gold nanoparticles for nano- and bio-photonic applications – Associate Professor James Chon
Antigen-induced T cell arrest: the role of membrane tension
Engaging the public with imaging science
Increasing XFEL beamtime success through enhanced protein crystal screening
Research assistant wanted – Davidovich Lab
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
A stochastic hill climbing approach for simultaneous 2D alignment and clustering of cryo-EM images
TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
Researchers awarded Australian Laureate Fellowships
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
CRYSTAL 30: advancing crystallography in the science community
Showcasing inspiring projects from next-generation imaging scientists
Public T cell receptors confer high-avidity CD4 responses to HIV controllers
Research uncovers ‘local heroes’ of immune system
Snapshots of the immune system
Dale Godfrey talks: immunology
Discovery tour
Melbourne Knowledge Week Public Lecture
Antoine van Oijen CoE AI – Biology at the nanoscale, one molecule at a time
Hans Elmlund on ABC Radio, Health Report
Falling Walls Labs Australia calling …
The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1
An iterative method for robust in-line phase contrast imaging
Questions and controversies in innate immune research: what is the physiological role of NLRP3?
One stop flu shot…?
Dr Stephanie Gras on ABC Weekend Breakfas
Dr Stephanie Gras on a universal flu vaccine
Molecular basis for universal HLA-A*0201–restricted CD8+ T-cell immunity against influenza viruses
Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity, and increased Parvalbumin-positive cortical interneuron density
Australian flu research raises hopes for universally effective vaccine
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.
Tick spit proteins could hold medical key
Structural basis for therapeutic inhibition of complement C5
Measuring membrane association and protein diffusion within membranes with supercritical angle fluorescence microscopy
Half a million dollar tick
Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness
A biased view toward celiac disease
Laura McKay CoE AI – Development and function of tissue resident lymphocytes
Broadband x-ray ptychography
It was MASSIVE
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
Capturing the Structure of the Substrate Bound Condensation Domain.
Three dimensional reconstruction of the size and shape of protein microcrystals using Bragg coherent diffractive imaging
HIV-1–Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection
Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells
Partially coherent contrast-transfer-function approximation
Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells
Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015)
N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin
A workshop on Nature’s Method of the Year
How the immune system punches holes in bacteria
Inspiring the next generation
MAIT cells are systemically depleted in SIV-infected rhesus macaques
Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases
Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation
Structure of OxyAtei : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade
Atypical Natural Killer T-cell receptor recognition of CD1d-lipid antigens
New population of human T cells
Whole-pattern fitting technique in serial femtosecond nanocrystallography
Broadband x-ray ptychography
Annexin A6 regulates interleukin-2-mediated T-cell proliferation
Structure of the poly-C9 component of the Complement Membrane Attack complex
Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages
Leibniz-DAAD Research Fellowships
Call for applications: Premier’s Award for Health & Medical Research 2016
Soluble LILRA3 promotes neurite outgrowth and synapses formation through high affinity interaction with Nogo 66
Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases
The E3 ubiquitin ligase RNF144B is LPS-inducible in human, but not mouse, macrophages and promotes inducible IL-1β expression.
Driving online engagement with cutting-edge research
A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics
Co-transcriptomic Analysis by RNA Sequencing to Simultaneously Measure Regulated Gene Expression in Host and Bacterial Pathogen
Diversity of T Cells Restricted by the MHC Class IRelated Molecule MR1 Facilitates Differential Antigen Recognition
Postdoctoral Research Fellows — Immunity
Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer
High-density grids for efficient data collection from multiple crystals
An afternoon with Nobel Laureate, William E. Moerner
Confocal microscopy: Past, present and future
Tissue-resident memory T cells: local specialists in immune defence
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate
Congratulations to Imaging CoE AI Michelle Dunstone
Inspiring the next generation
Our people; their vision, their research: our passion.
Deadly blessing? Stonefish venom could hold the key to understanding the immune system
Broadband chirality-coded meta-aperture for photon-spin resolving
Stonefish toxin defines an ancient branch of the perforin-like superfamily
Big win for researchers unlocking the secrets of the immune system
Kat Gaus speaks at a Korean-German Science Innovation Conference
Fruit fly embryos, human growth factors, the press
Human autoreactive T cells recognize CD1b and phospholipids
A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron
Giant MACPF/CDC pore forming toxins: A class of their own
Membrane-anchored Serine Protease Matriptase is a Trigger of Pulmonary Fibrogenesis
Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians
Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation
High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans
Plasmon-Enhanced Sensing: Current Status and Prospects
Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini
Toward peptide-based inhibitors as therapies for Parkinson’s disease
Making heads and tails of embryo development: lessons from the humble fly
Dr Hugh Reid talks
Safer and more comfortable breast cancer screening on the horizon
World’s largest electron microscope manufacturer heads Down Under for R&D
On-chip photonic Fourier transform with surface plasmon polaritons
Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships
Single-molecule imaging with longer X-ray laser pulses
The burgeoning family of unconventional T cells
Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells.
The aPKC/Par3/Par6 polarity complex and membrane order are functionally inter-dependent in epithelia during vertebrate organogenesis
Flexibility versus Rigidity for Orally Bioavailable Cyclic Hexapeptides
Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2
Turning T cell immunology on its head
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.
Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry
Unravelling the immune killing process
Engaging the masses with science
Igniting innovation at the Imaging CoE Summit 2015
2015 Annual Report
Lipid and small-molecule display by CD1 and MR1
Enhancing quantum dots for bioimaging using advanced surface chemistry and advanced optical microscopy: application to silicon quantum dots (SiQDs)
Exposing the immune system
Revealing the next generation of science
A killer award for killer T cells
Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists
Ultrasensitive and Specific Measurement of Protease Activity Using Functionalized Photonic Crystals
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Exposing the immune system
Spatiotemporally distinct interactions with DC subsets facilitates CD4 and CD8 T cell activation to localized viral infection
A bird’s eye view of NK cell receptor interactions with their MHC class I ligands.
World’s leading supplier of electron microscopy solutions partners with Imaging CoE for R&D
A killer award for killer T cells
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells
Ubiquitous Structural Signaling in Bacterial Phytochromes
Clinical application of low-dose phase contrast breast CT: methods for the optimization of the reconstruction workflow
Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA
Exploring the frontiers of nano-imaging
The future of structural biology is now
Engaging with the global biotechnology industry
Exploring the frontiers of nano-imaging
Engaging with the global biotechnology industry
The future of structural biology is now
Tc17 cells are a pro-inflammatory, plastic lineage of pathogenic CD8+ T-cells that induce GVHD without anti-leukemic effects.
Spontaneous retrotransposon insertion into TNF 3’UTR causes heart valve disease and chronic polyarthritis.
3D structure of individual nanocrystals in solution by electron microscopy
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Elemental mapping of the entire intact Drosophila gastrointestinal tract.
Emphasis on Outreach
Inspiring the next generation of scientists
Exploring the biomedical mechanisms behind coeliac disease
Neutron Strain Tomography using the Radon Transform
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells
Identification of phenotypically and functionally heterogeneous mouse Mucosal Associated Invariant T cells using MR1-antigen tetramers
Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites
Downsizing Proteins Without Losing Potency or Function
Caught on camera: the first glimpse of powerful nanoparticles
Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites
Imaging transient melting of a nanocrystal using an x-ray laser
The myelin proteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgi complex
Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery
Perforin and granzymes: function, dysfunction and human pathology
Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens
Krüppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets.
Endolymphatic hydrops is prevalent in the first weeks following cochlear implantation
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists
Determinants of Gliadin-Specific T Cell Selection in Celiac Disease
STAT3 is a critical cell-intrinsic regulator of human unconventionalT cell numbers and function
Paired TCRαβ analysis of virus-specific CD8+ T cells exposes diversity in a previously defined ‘narrow’ repertoire
Radiation damage in a micron-sized protein crystal studied via reciprocal space mapping and Bragg coherent diffractive imaging
The linac coherent light source single particle imaging road map
T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells
Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis
Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase
The structure of the atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4.
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
Tracking molecular dynamics without tracking: image correlation of photo-activation microscopy
Peptide-dependent recognition of HLA-B*57:01 by KIR3DS1
X-Ray Imaging of a Single Virus in 3D
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids.
Continuous motion scan ptychography : characterization for increased speed in coherent x-ray imaging
Simultaneous cryo X-ray ptychographic and fluorescence microscopy of a marine algae
CD3(bright) signals on γδ T cells identify IL-17A-producing Vγ6Vδ1(+) T cells.
MAIT cells are depleted early but retain functional cytokine expression in HIV infection.
Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Carnivorous mushrooms reveal human immune trick
αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands
Self-Calibrated Line-Scan STED-FCS to Quantify Lipid Dynamics in Model and Cell Membranes
A titanic electron microscope that snap-freezes cells to reveal immune secrets
Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets
Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens
An RPTPα/Src Family Kinase /Rap1 signaling module recruits Myosin IIB to support contractile tension at apical E-cadherin junctions.
Ultrafast self-gating Bragg diffraction of exploding nanocrystals in an X-ray laser
MR1 presentation of vitamin B-based metabolite ligands
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue
Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception.
Understanding the complexity and malleability of T-cell recognition.
Diversity of T Cells Restricted by the MHC Class IRelated Molecule MR1 Facilitates Differential Antigen Recognition
GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome.
Reconstitution of GPCRs in Lipidic Cubic Phase (LCP):Comparison between human Histamine 1 and Dopamine 2Long receptor reconstitution into five different self-assembly lipids
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
The molecular bases of δ/αβ T cell–mediated antigen recognition
Molecular architecture of the αβT cell receptor-CD3 complex
Uptake of the butyrate receptors, GPR41 and GPR43, in lipidic bicontinuous cubic phases suitable for in meso crystallization
Constraining cyclic peptides to mimic protein structure motifs
Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable
MAIT cells are depleted early but retain functional cytokine expression in HIV infection.
Mapping biological composition through quantitative phase and absorption X-ray ptychography
An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant.
Potent Heterocyclic Ligands for Human Complement C3a Receptor
Skin DCs cluster for efficient T cell activation.
2014 Annual Report
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.
Fresnel coherent diffractive imaging tomography of whole cells in capillaries
Stereoelectronic Effects Dictate Molecular Conformation and Biological Function of Heterocyclic Amides.
The Cellular Redox Environment Alters Antigen Presentation
A New Model for Pore Formation by Cholesterol-Dependent Cytolysins
Distinct APC subtypes drive spatially segregated helper versus killer T-cell effector activity during skin infection with HSV-1
Rapid, low dose X-ray diffractive imaging of the malaria parasite Plasmodium falciparum, Ultramicroscopy
Cyclic Penta- and Hexa- Leucine Peptides Without N-Methylation Are Orally Absorbed
Characterisation of Residual Stress due to Fillet Rolling on Bolts Made of a Nickel Base Superalloy
A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells
The Glucocorticoid Receptor 1A3 Promotor correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes
Tissue-resident T cells: dynamic players in skin immunity
Imaging Lattice Dynamics in Individual Nanocrystals
Pathway-selective antagonism of proteinase activated receptor 2
Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire.
Ptychographic Fresnel coherent diffraction tomography at the nanoscale
Comparative α-Helicity of Cyclic Pentapeptides in Water
The structure of the cytomegalovirus-encoded m04 glycoprotein, a prototypical member of the m02 family of immunoevasins
Biointerfaces on Indium–Tin Oxide Prepared from Organophosphonic Acid Self-Assembled Monolayers
A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
Ultrafast Imaging of Shocked Material Dynamics with X-ray Fee Electron Laser Pulses
Key interactions for clathrin coat stability
Antibody Modified Porous Silicon Microparticles for the Selective Capture of Cells
Rich tomography techniques for the analysis of microstructure and deformation
Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes
Reconciling the structural attributes of avian antibodies
CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria
Galectin-3 drives glycosphingolipid-dependent biogenensis of clathrin-independent carriers.
The organisation of the cell membrane: do proteins rule lipids?
Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche
T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease
High resolution structure of cleaved Serpin 42Da from Drosophila melanogaster
Versatile “Click Chemistry” Approach to Functionalizing Silicon Quantum Dots: Applications toward Fluorescent Cellular Imaging
Persistence of skin-resident memory T cells within an epidermal niche
Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis
T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Molecularly Engineered Surfaces for Cell Biology: From Static to Dynamic Surfaces
The Perforin Pore Facilitates the Delivery of Cationic Cargos
Method for co-cluster analysis in multichannel single-molecule localisation data
Insights into adhesion biology using single-molecule localization microscopy
Local regularization of tilt projections reduces artifacts in electron tomography, Journal of Structural Biology
TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire
Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like
Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation
Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire
CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens
Fluorescence spectral correlation spectroscopy (FSCS) for probes with highly overlapping emission spectra
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Maspin is not required for embryonic development or tumour suppression
Dynamic control of beta 1 integrin adhesion by the plexinD1-sema3E axis
