While our Centre is composed of chemists, immunologists, physicists, structural biologists, single molecule scientists and biophysicists, we break these down into nine research themes which cover three key disciplines: immunology, chemistry and physics. The researchers within these disciplines are engaged in the application and fundamental development of imaging, for the mutual benefit of all.
MOLECULAR MOVIES USING XFEL
We are actively working on techniques to capture real-time molecular movies using ultrafast X-ray diffraction. Molecular movies using XFELs could allow scientists to track the intricacies, nuances and detailed behaviour of molecules like never before.
SINGLE MOLECULE IMAGING
We are addressing the challenges associated with instrument fluctuations, electronic damage, natural conformational variability and the effects of confinement by developing new systems and tools to map the heterogeneity landscape of single molecules.
MOLECULAR IMAGING OF T CELLS
To further understand how antigens elicit an immune response, we use single molecule imaging and other fluorescence techniques to map intracellular signalling processes.
IN VIVO IMAGING
We are working to solve major questions about immune cell interactions, how responses are initiated and how various cells co-ordinate their functions. Using sophisticated imaging techniques, we enable visualization of multiple cellular interactions in real-time.
IMAGING METABOLITE-MEDIATED IMMUNITY
Using our novel imaging reagents and imaging modalities developed within this theme, we are beginning to understand MAIT cell antigen recognition, activation, development and maintenance, and how these cells traffic in the host in response to infection.
IMAGING IMMUNE EFFECTORS
We are working to gain a better understanding of the control of the immune cascades governed by the Complement system. In the longer term we hope to use this information to control Complement, in a range of different diseases.