Research programs

While our Centre is composed of chemists, immunologists, physicists, structural biologists, single molecule scientists and biophysicists, we break these down into nine research themes which cover three key disciplines: immunology, chemistry and physics. The researchers within these disciplines are engaged in the application and fundamental development of imaging, for the mutual benefit of all.

IMAGING

MOLECULAR MOVIES USING XFEL

We are actively working on techniques to capture real-time molecular movies using ultrafast X-ray diffraction. Molecular movies using XFELs could allow scientists to track the intricacies, nuances and detailed behaviour of molecules like never before.

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SINGLE MOLECULE IMAGING

We are addressing the challenges associated with instrument fluctuations, electronic damage, natural conformational variability and the effects of confinement by developing new systems and tools to map the heterogeneity landscape of single molecules.

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MOLECULAR IMAGING OF T CELLS

To further understand how antigens elicit an immune response, we use single molecule imaging and other fluorescence techniques to map intracellular signalling processes.

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IN VIVO IMAGING

We are working to solve major questions about immune cell interactions, how responses are initiated and how various cells co-ordinate their functions. Using sophisticated imaging techniques, we enable visualization of multiple cellular interactions in real-time.

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IMMUNOLOGY

IMAGING PEPTIDE-MEDIATED IMMUNITY

By developing atomic and molecular imaging innovations, our research can further understand T cell function and dysfunction.

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IMAGING LIPID-MEDIATED IMMUNITY

We are investigating the types of lipids that are responsible for lipid mediated immunity in the context of both foreign and self-antigens.

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IMAGING METABOLITE-MEDIATED IMMUNITY

Using our novel imaging reagents and imaging modalities developed within this theme, we are beginning to understand MAIT cell antigen recognition, activation, development and maintenance, and how these cells traffic in the host in response to infection.

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IMAGING INNATE IMMUNE RESPONSES

We are working to uncover what happens over time when cells of the innate immune system are confronted with infectious and non-infectious stimuli.

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IMAGING IMMUNE EFFECTORS

We are working to gain a better understanding of the control of the immune cascades governed by the Complement system. In the longer term we hope to use this information to control Complement, in a range of different diseases.

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