SEMINAR WITH PROFESSOR DAVID BAKER

SEMINAR WITH PROFESSOR DAVID BAKER

Start Date: 22 May 2020 – 10:30 am
End Date: 22 May 2020 – 11.30 am
Zoom link: https://latrobe.zoom.us/j/95286554278
Meeting ID: 952 8655 4278
For additional information, please contact Prof. Brian Abbey
E: B.Abbey@latrobe.edu.au

    • Category: Events
    • Date: May 21, 2020
    • Added By: ImagingCoE

PROFESSOR DAVID BAKER
Howard Hughes Medical Institute, University of Washington

The coming of age of de novo protein design.”

Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address current day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, we design new proteins from scratch based on Anfinsen’s principle that proteins fold to their global free energy minimum. We compute amino acid sequences predicted to fold into proteins with new structures and functions, produce synthetic genes encoding these sequences, and characterize them experimentally. I will describe the de novo design of fluorescent proteins, membrane penetrating macrocycles, transmembrane protein channels, allosteric proteins that carry out logic operations, and self-assembling protein unbounded 1 and 2D materials and polyhedra.

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