Our biological aims are to understand how the mechanisms for transcription initiation and start-site selection differ between constitutively transcribed (housekeeping) and stress-inducible genes by studying the large but transient protein-protein and protein-DNA complexes involved using a combination of techniques, including cryo-EM, mass-spectrometry and biochemical assays.
We have three positions available:
- Postdoctoral fellow — molecular basis of stress-inducible gene regulation
- Postdoctoral fellow — transcription coupled chromatin remodeling
- Scientific programmer — image processing for single-particle cryo-EM
Monash University is a leading research university in Australia and has received a rank of 67 worldwide in the 2015/16 report from QS world university rankings. State-of-the-art technology is available to all projects via Monash’s Technology Research Platforms strategy, with the Monash Ramaciotti Centre for Cryo-EM housing a Titan KRIOS with K2 detector, energy filter and Volta phase plate. Extensive computational infrastructure is also available through the MASSIVE M3 supercomputer.
The excellent structural biology community surrounding the facility, the nearby Australian Synchrotron and other major research programs, such as the ARC Centre of Excellence in Advanced Molecular Imaging (led by Monash), provides a unique opportunity to execute the projects.
To find out more about the positions and our research, please visit simplecryoem.com.
Download the position descriptions: Elmlund Lab — PDs