April 13, 2016

Antoine van Oijen CoE AI – Biology at the nanoscale, one molecule at a time

Presenter: Antoine van Oijen, School of Chemistry, University of Wollongong

Date: 21 April 2016

Time 12.00pm – 1.00pm

Location: Level 3 Seminar Room, 15 Innovation Walk, Monash University, Clayton Campus


Our group is interested in combining fluorescence imaging approaches with molecular manipulation techniques to study biological processes at the single-molecule level. By recording ‘molecular movies’ of individual enzymes we hope to gain new insight into reaction dynamics and mechanisms. In a biological context, most of these enzymes function in concert with other enzymes in multi-protein complexes, so an important direction is the utilization of single-molecule techniques to unravel the orchestration of large macromolecular assemblies. I will discuss recent results of single-molecule studies of the protein machinery responsible for DNA replication. We visualize the dynamic behavior of replication complexes during replication and unravel mechanistic working principles that challenge aspects of the existing textbook view of replication.

For more details download the event flyer:

Apr21 Antoine van Oijen I&I